The European Space Agency (ESA) defines Earth observation (EO) Level 2 information product the stack of: (i) a single-date multi-spectral (MS) image, radiometrically corrected for atmospheric, adjacency and topographic effects, with (ii) its data-derived scene classification map (SCM), whose thematic map legend includes quality layers cloud and cloudshadow. Never accomplished to date in an operating mode by any EO data provider at the ground segment, systematic ESA EO Level 2 product generation is an inherently ill-posed computer vision (CV) problem (chicken-and-egg dilemma) in the multi-disciplinary domain of cognitive science, encompassing CV as subset-of artificial general intelligence (AI). In such a broad context, the goal of our work is the research and technological development (RTD) of a “universal” AutoCloud+ software system in operating mode, capable of systematic cloud and cloudshadow quality layers detection in multi-sensor, multi-temporal and multi-angular EO big data cubes characterized by the five Vs, namely, volume, variety, veracity, velocity and value. For the sake of readability, this paper is divided in two. Part 1 highlights why AutoCloud+ is important in a broad context of systematic ESA EO Level 2 product generation at the ground segment. The main conclusions of Part 1 are both conceptual and pragmatic in the definition of remote sensing best practices, which is the focus of efforts made by intergovernmental organizations such as the Group on Earth Observations (GEO) and the Committee on Earth Observation Satellites (CEOS). First, the ESA EO Level 2 product definition is recommended for consideration as state-of-the-art EO Analysis Ready Data (ARD) format. Second, systematic multi-sensor ESA EO Level 2 information product generation is regarded as: (a) necessary-but-not-sufficient pre-condition for the yet-unaccomplished dependent problems of semantic content-based image retrieval (SCBIR) and semantics-enabled information/knowledge discovery (SEIKD) in multi-source EO big data cubes, where SCBIR and SEIKD are part-of the GEO-CEOS visionary goal of a yet-unaccomplished Global EO System of Systems (GEOSS). (b) Horizontal policy, the goal of which is background developments, in a “seamless chain of innovation” needed for a new era of Space Economy 4.0. In the subsequent Part 2 (proposed as Supplementary Materials), the AutoCloud+ software system requirements specification, information/knowledge representation, system design, algorithm, implementation and preliminary experimental results are presented and discussed.