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Title
Developmental changes of sleep spindles and their impact on sleep-dependent memory consolidation and general cognitive abilities : A longitudinal approach
AuthorHahn, Michael ; Joechner, Ann-Kathrin ; Roell, Judith ; Schabus, Manuel ; Heib, Dominik PJ ; Gruber, Georg ; Peigneux, Philippe ; Hoedlmoser, Kerstin
Published in
Developmental Science, 2019, Vol. 22, Issue 1, page e12706
Published2019
LanguageEnglish
Document typeJournal Article
Project-/ReportnumberThe Austrian Science Fund (T397-B02 & P25000)
Project-/ReportnumberDoctoral College ‘Imaging the Mind (Austrian Science Fund W1233)
Project-/ReportnumberThe Jacobs Foundation (JS1112H)
URNurn:nbn:at:at-ubs:3-10367 Persistent Identifier (URN)
DOI10.1111/desc.12706 
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 The work is publicly available
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Developmental changes of sleep spindles and their impact on sleep-dependent memory consolidation and general cognitive abilities [1.01 mb]
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Abstract (English)

Sleep spindles are related to sleepdependent memory consolidation and general cognitive abilities. However, they undergo drastic maturational changes during adolescence. Here we used a longitudinal approach (across 7 years) to explore whether developmental changes in sleep spindle density can explain individual differences in sleepdependent memory consolidation and general cognitive abilities. Ambulatory polysomnography was recorded during four nights in 34 healthy subjects (24 female) with two nights (baseline and experimental) at initial recording (age range 811 years) and two nights at followup recording (age range 1418 years). For declarative learning, participants encoded word pairs with a subsequent recall before and after sleep. General cognitive abilities were measured by the Wechsler Intelligence Scale. Higher slow (1113 Hz) than fast (1315 Hz) spindle density at frontal, central, and parietal sites during initial recordings, followed by a shift to higher fast than slow spindle density at central and parietal sites during followup recordings, suggest that mature spindle topography develops throughout adolescence. Fast spindle density increases from baseline to experimental night were positively related to sleepdependent memory consolidation. In addition, we found that the development of fast spindles predicted the improvement in memory consolidation across the two longitudinal measurements, a finding that underlines a crucial role for mature fast spindles for sleepdependent memory consolidation. Furthermore, slow spindle changes across adolescence were related to general cognitive abilities, a relationship that could indicate the maturation of frontal networks relevant for efficient cognitive processing. A video abstract of this article can be viewed at: https://www.youtube.com/watch?v=7NXJzm8HbIw and https://www.youtube.com/watch?v=iuMQY1OIJ0s

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CC-BY-License (4.0)Creative Commons Attribution 4.0 International License