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ProSA-web : interactive web service for the recognition of errors in three-dimensional structures of proteins
VerfasserWiederstein, Markus ; Sippl, Manfred J.
Erschienen in
Nucleic Acids Research, Oxford, 2007, Jg. 35, H. suppl_2, S. W407-W410
ErschienenOxford University Press, 2007
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)diagnostic radiologic examination / roentgen rays / exercise / internet / models, theoretical / spectrum analysis / protein structure / molecule
URNurn:nbn:at:at-ubs:3-6213 Persistent Identifier (URN)
 Das Werk ist frei verfügbar
ProSA-web [2.41 mb]
Zusammenfassung (Englisch)

A major problem in structural biology is the recognition of errors in experimental and theoretical models of protein structures. The ProSA program (Protein Structure Analysis) is an established tool which has a large user base and is frequently employed in the refinement and validation of experimental protein structures and in structure prediction and modeling. The analysis of protein structures is generally a difficult and cumbersome exercise. The new service presented here is a straightforward and easy to use extension of the classic ProSA program which exploits the advantages of interactive web-based applications for the display of scores and energy plots that highlight potential problems spotted in protein structures. In particular, the quality scores of a protein are displayed in the context of all known protein structures and problematic parts of a structure are shown and highlighted in a 3D molecule viewer. The service specifically addresses the needs encountered in the validation of protein structures obtained from X-ray analysis, NMR spectroscopy and theoretical calculations. ProSA-web is accessible at https://prosa.services.came.sbg.ac.at.