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A novel genetic variant in long non-coding RNA gene NEXN-AS1 is associated with risk of lung cancer
VerfasserYuan, Hua ; Liu, Hongliang ; Liu, Zhensheng ; Owzar, Kouros ; Han, Younghun ; Su, Li ; Su, Li ; Wei, Yongyue ; Hung, Rayjean J. ; McLaughlin, John ; Brhane, Yonathan ; Brennan, Paul ; Bickeboeller, Heike ; Rosenberger, Albert ; Houlston, Richard S. ; Caporaso, Neil ; Landi, Maria Teresa ; Heinrich, Joachim ; Risch, Angela ; Christiani, David C.
Erschienen in
Scientific Reports, London, 2016, Jg. 6, S. 1-8
ErschienenNature Publishing Group, 2016
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)Cancer epidemiology / Cancer genomics
ISSN2045-2322
URNurn:nbn:at:at-ubs:3-4459 Persistent Identifier (URN)
DOI10.1038/srep34234 
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A novel genetic variant in long non-coding RNA gene NEXN-AS1 is associated with risk of lung cancer [0.82 mb]
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Zusammenfassung (Englisch)

Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium in populations of European ancestry. Previously unreported significant SNPs (P value<1107) were further validated in two additional independent lung cancer GWAS datasets from Harvard University and deCODE. In the final meta-analysis of all eight GWAS datasets with 17,153 cases and 239,337 controls, a novel risk SNP rs114020893 in the lncRNA NEXN-AS1 region at 1p31.1 remained statistically significant (odds ratio=1.17; 95% confidence interval=1.111.24; P=8.31109). In further in silico analysis, rs114020893 was predicted to change the secondary structure of the lncRNA. Our finding indicates that SNP rs114020893 of NEXN-AS1 at 1p31.1 may contribute to lung cancer susceptibility.

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