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Title
The initial inflammatory response to bioactive implants is characterized by NETosis
AuthorVitkov, Ljubomir ; Krautgartner, Wolf-Dietrich ; Obermayer, Astrid ; Stoiber, Walter ; Hannig, Matthias ; Klappacher, Michaela ; Hartl, Dominik
Published in
PLoS ONE, Lawrence, Kan. : Public Library of Science, 2015, Vol. 10, Issue 3: e0121359, page 1-13
LanguageEnglish
Document typeJournal Article
Keywords (EN)Platelets / Inflammation / Titanium / Blood / Scanning electron microscopy / Neutrophils / Fluorescence microscopy / Confocal laser microscopy
ISSN1932-6203
URNurn:nbn:at:at-ubs:3-3924 Persistent Identifier (URN)
DOI10.1371/journal.pone.0121359 
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 The work is publicly available
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The initial inflammatory response to bioactive implants is characterized by NETosis [1.34 mb]
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Abstract (English)

Implants trigger an inflammatory response, which is important for osseointegration. Here we studied neutrophil extracellular trap (NET) release of human neutrophils in response to sandblasted large-grit acid etched (SLA) implants using fluorescent, confocal laser scanning and scanning electron microscopy. Our studies demonstrate that human neutrophils rapidly adhered to SLA surfaces, which triggered histone citrullination and NET release. Further studies showed that albumin or acetylsalicylic acid had no significant effects on the inflammatory response to SLA surfaces. In contrast to bioinert materials, which do not osseointegrate, the bioactivity of SLA surfaces is coupled with the ability to release NETs. Further investigations are necessary for clarifying the role of NETosis for osseointegration.

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CC-BY-License (4.0)Creative Commons Attribution 4.0 International License