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Slow oscillation amplitudes and up-state lengths relate to memory improvement
VerfasserHeib, Dominik P. J. ; Hoedlmoser, Kerstin ; Anderer, Peter ; Zeitlhofer, Josef ; Gruber, Georg ; Klimesch, Wolfgang ; Schabus, Manuel
Erschienen in
PLoS ONE, Lawrence, Kan., 2013, Jg. 8, S. 1-9
ErschienenPublic Library of Science, 2013
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)Memory / Sleep / Recall (memory) / Learning / Long-term memory / Signal filtering / Memory consolidation / Electroencephalography
URNurn:nbn:at:at-ubs:3-2213 Persistent Identifier (URN)
 Das Werk ist frei verfügbar
Slow oscillation amplitudes and up-state lengths relate to memory improvement [0.61 mb]
Zusammenfassung (Englisch)

There is growing evidence of the active involvement of sleep in memory consolidation. Besides hippocampal sharp wave-ripple complexes and sleep spindles, slow oscillations appear to play a key role in the process of sleep-associated memory consolidation. Furthermore, slow oscillation amplitude and spectral power increase during the night after learning declarative and procedural memory tasks. However, it is unresolved whether learning-induced changes specifically alter characteristics of individual slow oscillations, such as the slow oscillation up-state length and amplitude, which are believed to be important for neuronal replay. 24 subjects (12 men) aged between 20 and 30 years participated in a randomized, within-subject, multicenter study. Subjects slept on three occasions for a whole night in the sleep laboratory with full polysomnography. Whereas the first night only served for adaptation purposes, the two remaining nights were preceded by a declarative word-pair task or by a non-learning control task. Slow oscillations were detected in non-rapid eye movement sleep over electrode Fz. Results indicate positive correlations between the length of the up-state as well as the amplitude of both slow oscillation phases and changes in memory performance from pre to post sleep. We speculate that the prolonged slow oscillation up-state length might extend the timeframe for the transfer of initial hippocampal to long-term cortical memory representations, whereas the increase in slow oscillation amplitudes possibly reflects changes in the net synaptic strength of cortical networks.

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