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Titel
4-Hydroxy-nonenal : a bioactive lipid peroxidation product
VerfasserSchaur, Rudolf J. ; Siems, Werner ; Bresgen, Nikolaus In der Gemeinsamen Normdatei der DNB nachschlagen ; Eckl, Peter In der Gemeinsamen Normdatei der DNB nachschlagen
Erschienen in
Biomolecules, Basel, 2015, Jg. 5, H. 4, S. 2247-2337
ErschienenMDPI, 2015
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)4-hydroxy-nonenal / HNE / n-6 polyunsaturated fatty acids / Michael adducts / mercapturic acid
URNurn:nbn:at:at-ubs:3-1581 Persistent Identifier (URN)
DOI10.3390/biom5042247 
Zugriffsbeschränkung
 Das Werk ist frei verfügbar
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4-Hydroxy-nonenal [1.55 mb]
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Zusammenfassung (Englisch)

This review on recent research advances of the lipid peroxidation product 4-hydroxy-nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues, II. the diverse biochemical reactions with Michael adduct formation as the most prominent one, III. the endogenous targets of HNE, primarily peptides and proteins (here the mechanisms of covalent adduct formation are described and the (patho-) physiological consequences discussed), and IV. the metabolism of HNE leading to a great number of degradation products, some of which are excreted in urine and may serve as non-invasive biomarkers of oxidative stress.

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CC-BY-Lizenz (4.0)Creative Commons Namensnennung 4.0 International Lizenz