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Title
4-Hydroxy-nonenal : a bioactive lipid peroxidation product
AuthorSchaur, Rudolf J. ; Siems, Werner ; Bresgen, Nikolaus In der Gemeinsamen Normdatei der DNB nachschlagen ; Eckl, Peter In der Gemeinsamen Normdatei der DNB nachschlagen
Published in
Biomolecules, Basel, 2015, Vol. 5, Issue 4, page 2247-2337
PublishedMDPI, 2015
LanguageEnglish
Document typeJournal Article
Keywords (EN)4-hydroxy-nonenal / HNE / n-6 polyunsaturated fatty acids / Michael adducts / mercapturic acid
URNurn:nbn:at:at-ubs:3-1581 Persistent Identifier (URN)
DOI10.3390/biom5042247 
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 The work is publicly available
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Abstract (English)

This review on recent research advances of the lipid peroxidation product 4-hydroxy-nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues, II. the diverse biochemical reactions with Michael adduct formation as the most prominent one, III. the endogenous targets of HNE, primarily peptides and proteins (here the mechanisms of covalent adduct formation are described and the (patho-) physiological consequences discussed), and IV. the metabolism of HNE leading to a great number of degradation products, some of which are excreted in urine and may serve as non-invasive biomarkers of oxidative stress.

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CC-BY-License (4.0)Creative Commons Attribution 4.0 International License