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Titel
Oxidative stress and the homeodynamics of iron metabolism
VerfasserBresgen, Nikolaus ; Eckl, Peter M.
Erschienen in
Biomolecules, Basel, 2015, Jg. 5, H. 2, S. 808-847
ErschienenMultidisciplinary Digital Publishing Institute, 2015
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)iron / oxidative stress / metabolism
URNurn:nbn:at:at-ubs:3-1541 Persistent Identifier (URN)
DOI10.3390/biom5020808 
Zugriffsbeschränkung
 Das Werk ist frei verfügbar
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Oxidative stress and the homeodynamics of iron metabolism [1.17 mb]
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Zusammenfassung (Englisch)

Iron and oxygen share a delicate partnership since both are indispensable for survival, but if the partnership becomes inadequate, this may rapidly terminate life. Virtually all cell components are directly or indirectly affected by cellular iron metabolism, which represents a complex, redox-based machinery that is controlled by, and essential to, metabolic requirements. Under conditions of increased oxidative stressi.e., enhanced formation of reactive oxygen species (ROS)however, this machinery may turn into a potential threat, the continued requirement for iron promoting adverse reactions such as the iron/H2O2-based formation of hydroxyl radicals, which exacerbate the initial pro-oxidant condition. This review will discuss the multifaceted homeodynamics of cellular iron management under normal conditions as well as in the context of oxidative stress.

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CC-BY-Lizenz (4.0)Creative Commons Namensnennung 4.0 International Lizenz