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Title
Interaction of nanoparticles with proteins : relation to bio-reactivity of the nanoparticle
AuthorSaptarshi, Shruti R. ; Duschl, Albert Josef In der Gemeinsamen Normdatei der DNB nachschlagen ; Lopata, Andreas L.
Published in
Journal of Nanobiotechnology, London, 2013, Vol. 11, Issue 26, page 1-12
PublishedBioMed Central, 2013
DescriptionDiagramme
LanguageEnglish
Document typeJournal Article
Keywords (EN)Nanaoparticle / Protein corona / Proteein unfolding / Nanoparticle uptake / Circular dichroism
ISSN1477-3155
URNurn:nbn:at:at-ubs:3-427 Persistent Identifier (URN)
DOI10.1186/1477-3155-11-26 
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 The work is publicly available
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Abstract (English)

Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. Furthermore, the nanoparticle surface can induce conformational changes in adsorbed protein molecules which may affect the overall bio-reactivity of the nanoparticle. In depth understanding of such interactions can be directed towards generating bio-compatible nanomaterials with controlled surface characteristics in a biological environment. The main aim of this review is to summarise current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake.