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Regulation of the actin cytoskeleton in Helicobater
AuthorWessler, Silja ; Gimona, Mario ; Rieder, Gabriele
Published in
Regulation of the actin cytoskeleton in Helicobater, London, 2011, Vol. 9, Issue 27, page 1-9
PublishedBioMed Central, 2011
Document typeJournal Article
URNurn:nbn:at:at-ubs:3-366 Persistent Identifier (URN)
 The work is publicly available
Regulation of the actin cytoskeleton in Helicobater [1.38 mb]
Abstract (English)

Dynamic rearrangement of the actin cytoskeleton is a significant hallmark of Helicobacter pylori (H. pylori) infected

gastric epithelial cells leading to cell migration and invasive growth. Considering the cellular mechanisms, the type

IV secretion system (T4SS) and the effector protein cytotoxin-associated gene A (CagA) of H. pylori are well-studied

initiators of distinct signal transduction pathways in host cells targeting kinases, adaptor proteins, GTPases, actin

binding and other proteins involved in the regulation of the actin lattice. In this review, we summarize recent

findings of how H. pylori functionally interacts with the complex signaling network that controls the actin

cytoskeleton of motile and invasive gastric epithelial cells.